Shantha Biotech


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Infrastructure

Shantha is equipped with state-of-the-art R&D facility, ideally designed for development of biologics, based on modern biotechnology. The facility has 50,000 sq.ft of laboratory area, divided in four independent laboratories.


	1	Main Lab used for molecular biology, immunology, microbial fermentation, purification and characterization.
	2	Class 10,000 area facility for animal cell culture, hybridoma technology, virus handling and upstream and downstream process development.
	3	Bacterial vaccine lab
	4	Viral vaccine lab (with a separate cell culture and virus handling area)

The support facilities include a library, lecture hall, central monitoring system and other essential services like centralized vacuum, compressed air, cold rooms and circulating distilled water and other essentials for a modern industrial R&D laboratory.

Instrument Facilities

Automatic computer controlled bio-reactors of various capacities from 1L to 100L for microbial and mammalian cell culture provided with state-of-the-art accessories for exhaust gas analysis, perfusion and online nutrient and metabolite analysis.


	•	Cross-flow filtration systems of various types such as membrane, hollow fibre and ceramic, for handling filtration process upto a volume of 1000L.
	•	Continuous flow centrifuge for handling large-scale separation processes upto a volume of 500L.
	•	Homogenisers including a bead-mill and a high-pressure homogeniser for pilot scale cell disruption.
	•	Sophisticated computer controlled chromatography systems for laboratory and pilot scale protein purification along with axial and radial flow and expanded bed columns of various sizes.
	•	Pilot scale lyophilisers for asceptic freeze-drying.
	•	Dry heat and steam sterilising equipments.
	•	Online methanol sensor for monitoring Pichia based fermentations.

Other analytical instruments include Fluorescence and phase-contrast microscopes with camera and video attachments, Scanning Densitometer, Gel Documentation System, UV-VIS Spectrophotometer, Spectroflourimeter, HPCL, GC, Liquid Scintillation Counter, Oligonucleotide Synthesiser, Thermocyclers and Tunable UV-VIS Plate Reader.